We’re pioneering a unique and transformational approach to enhance the transfer of therapeutics into the brain and other targeted tissue

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Immune cells have the machinery to efficiently cross the Blood Brain Barrier (BBB)

Naïve T cells do not typically penetrate the BBB

Selective manipulation of T cells can significantly enhance the trafficking of T cells across barriers and into targeted tissues, including the brain

Capitalizes on the enhanced “hitchhiking” and intracerebral accumulation of macromolecules bound to the surface

APTN-101: Combination of BRiTE (drug molecule) with ACT addresses significant obstacles in treatment of brain cancers

BRiTE (Brain Bispecific T cell Engager) Given after infusion of activated T cells

One arm of BRiTE binds CD3 (receptor on all mature T cells)
Second arm of BRiTE specifically binds to tumor target (EGFVRIII)

Adoptive Cell Therapy (ACT)

Some of the patient’s immune cells are collected (leukapheresis)

T cells undergo manipulation and activation to express keys for penetration through the BBB (ex. VLA-4, LFA-1)

Activated T cells ready for reinfusion